Sam may refer to:
- Sam (barmaid), a barmaid at the Burthorpe Games Rooms
- Sam (cape merchant), a team cape merchant in the Wilderness
- Sam (Independence Day Celebration), a trader for the holiday event
- Sam the sheepdog
- H.A.M. agent Sam, an NPC in The Chosen Commander
- Speedy Sam The Striker, a famous Gnome Baller
- Squire Sam, a Void Knight involved in Quiet Before the Swarm
- Samuel, a now-removed NPC who lived in Lumbridge
- Samuel Scourduel, an explorer who wrote the lore story The Excellent Log of the Journeys and Tribulations of Samuel Scourduel
- Samuel LeBaux, an NPC involved in the 2015 April Fools event
- Samael Leynes, the author of the lore excerpt Conversations with a Mage
- Mod Sam J, a former Jagex Moderator
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